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Hereditary Spherocytosis

This Medical Laboratory Science lesson in Hematology supports laboratory science learning and laboratory interpretation for medical laboratory students and professionals.

Hereditary spherocytosis, spherocytes on smear, elevated MCHC, osmotic fragility/EMA binding concepts, and hemolytic marker pattern.

Intermediate32 min read18 sectionsHematology
Section 1 of 180%

Learning Objectives

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Section 1 of 18

Learning Objectives

Learning Objectives

Section: Learning Objectives

Laboratory medicine focus, patterns suggest differentials; confirmatory tests and clinical correlation establish diagnosis.

  • Recognize spherocyte pattern on peripheral smear
  • Correlate with elevated MCHC and hemolytic marker panel
  • Understand confirmatory testing concepts (osmotic fragility, EMA flow cytometry) per institutional menu
  • Distinguish from autoimmune hemolytic anemia using DAT

Section 1 of 18