Allergic Transfusion Reactions

This Medical Laboratory Science lesson in Blood Bank supports laboratory science learning and laboratory interpretation for medical laboratory students and professionals.

Perform the laboratory's investigation of a suspected allergic transfusion reaction after hemolysis has been excluded, history and prior-reaction review, product/plasma-content review, and documentation, without describing clinical treatment.

Intermediate24 min read15 sectionsBlood Bank
Section 1 of 150%

Learning Objectives

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Section 1 of 15

Learning Objectives

Learning Objectives

Section: Learning Objectives

Each objective below describes a transfusion-service laboratory competency, investigating and interpreting adverse transfusion reactions, not delivering bedside treatment.

  • Explain why hemolysis must be excluded before an urticarial/pruritic reaction is attributed to a routine allergic mechanism
  • Describe the laboratory's history and product-review actions for a suspected allergic transfusion reaction, prior reaction history, plasma content of the implicated component, and any documented sensitivities
  • Distinguish a routine (mild, localized) allergic transfusion reaction from a presentation severe enough to warrant escalation toward the anaphylaxis workup pathway