Overview
Directed platelet testing beyond automated CBC count and MPV.
Classification
| Test category | Purpose | Specimen notes |
|---|---|---|
| PFA closure time | Screen adhesion/aggregation pathway | Citrate; avoid recent antiplatelet agents per clinician order |
| Aggregometry | Confirm functional defect pattern | Fresh citrate; time-sensitive processing |
| von Willebrand panel | Adhesion defect workup when indicated | Separate coagulation specimen, clinician-directed |
| Molecular / flow | Inherited platelet disorder confirmation | Specialized referral laboratory |
Morphologic Features
Smear may show giant or hypogranular platelets, suggests but does not prove specific disorder.
Laboratory Characteristics
- Screening NOT definitive diagnosis, pattern support only
Reference Intervals
Assay-specific, verify on report.
Clinical and Laboratory Significance
Abnormal screen triggers reflex per protocol, not standalone disease label.
Differential Considerations
Comparison Tables
Classification Frameworks
Laboratory Notes
- CLSI H21 context for citrate coagulation specimens.
References
Authoritative textbooks, guidelines, and reviews supporting this reference entry. Verify reference intervals, critical limits, and reflex criteria against institutional protocols and current guideline editions.
Textbooks
- McPherson RA, Pincus MR. Henry's Clinical Diagnosis and Management by Laboratory Methods. 24th ed. Elsevier; 2021.
- Rodak BF, Carr JH. Rodak's Hematology: Clinical Principles and Applications. 6th ed. Elsevier; 2020.
- McKenzie SB, Williams JL. Clinical Laboratory Hematology. 4th ed. Pearson; 2022.
- Bain BJ. Blood Cells: A Practical Guide. 5th ed. Wiley-Blackwell; 2015.
CLSI and Professional Guidelines
- Clinical and Laboratory Standards Institute. Reference and Selected Performance Standards for the Automated Complete Blood Cell Count (CBC). CLSI document H26-A2. CLSI; 2010.
- Clinical and Laboratory Standards Institute. Defining, Establishing, and Verifying Reference Intervals in the Clinical Laboratory; Approved Standard. CLSI document EP28-A3c. CLSI; 2010.
- Clinical and Laboratory Standards Institute. Management of Critical- and Significant-Risk Results. CLSI guideline GP47-Ed1. CLSI; 2015.
- Clinical and Laboratory Standards Institute. Collection, Transport, and Processing of Blood Specimens for Testing Plasma-Based Coagulation Assays and Molecular Hemostasis Assays; Approved Guideline. CLSI document H21-A5. CLSI; 2017.
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