Overview
Hematopoiesis branches from HSC into myeloid and lymphoid pathways producing all major formed elements.
Classification
| Branch | Progenitor | Mature products |
|---|---|---|
| Myeloid, granulocytic | Granulocyte-monocyte progenitor | Neutrophils, eosinophils, basophils |
| Myeloid, erythroid | Erythroid progenitor | Erythrocytes |
| Myeloid, megakaryocytic | Megakaryocyte progenitor | Platelets |
| Myeloid, monocytic | Monocyte lineage | Monocytes / macrophages |
| Lymphoid | CLP | B, T, NK cells |
Morphologic Features
Lineage assignment precedes maturity staging on smear review.
Laboratory Characteristics
- Differential count, assigns broad lineage categories
- Lineage-specific maturation in dedicated Academy lessons
Reference Intervals
Per-lineage reference intervals are institution-specific, see CBC modules.
Clinical and Laboratory Significance
- Selective cytopenia, lineage-specific production issue
- Pancytopenia, broader marrow failure concern
Differential Considerations
Pattern recognition begins with lineage bucket before disease classification.
Comparison Tables
Lineage-first interpretation
| Question | First step |
|---|---|
| Low Hgb | Erythroid myeloid pathway |
| Low PLT | Megakaryocytic pathway |
| Low ANC | Granulocytic pathway |
| High lymphocytes % | Lymphoid pathway, absolute count |
Classification Frameworks
Neoplastic lineage restriction uses immunophenotype . WHO module later in curriculum.
Laboratory Notes
- Do not duplicate full maturation tables here, see lineage-specific library entries.
References
Authoritative textbooks, guidelines, and reviews supporting this reference entry. Verify reference intervals, critical limits, and reflex criteria against institutional protocols and current guideline editions.
Textbooks
- McPherson RA, Pincus MR. Henry's Clinical Diagnosis and Management by Laboratory Methods. 24th ed. Elsevier; 2021.
- Rodak BF, Carr JH. Rodak's Hematology: Clinical Principles and Applications. 6th ed. Elsevier; 2020.
- Hoffbrand AV, Moss PAH, Pettit JE. Essential Haematology. 8th ed. Wiley-Blackwell; 2019.
- McKenzie SB, Williams JL. Clinical Laboratory Hematology. 4th ed. Pearson; 2022.
Professional Monographs
- Barnes PW, McFadden SL, Machin SJ, Doig K. Laboratory Hematology Practice. Wiley-Blackwell; 2012.
CLSI and Professional Guidelines
- Clinical and Laboratory Standards Institute. Defining, Establishing, and Verifying Reference Intervals in the Clinical Laboratory; Approved Standard. CLSI document EP28-A3c. CLSI; 2010.
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