Overview
1:1 patient:normal pooled plasma mix interpretation lookup, verify institutional correction criteria.
Classification
| Immediate mix | Incubated mix (if performed) | Pattern association (not definitive) | Typical reflex |
|---|---|---|---|
| Corrects | Remains corrected | Factor deficiency | Specific factor assay |
| No correction | No correction | Inhibitor / LA | LA panel, Bethesda titer |
| Corrects | Re-prolongs | Time-dependent inhibitor | Factor VIII inhibitor workup |
| Partial correction | Variable | Multiple deficiencies or weak inhibitor | Repeat, factor panel per protocol |
Morphologic Features
Laboratory Characteristics
- Correction threshold institution-specific, do not assume universal 50% rule
Reference Intervals
Clinical and Laboratory Significance
Mixing studies screen deficiency vs inhibitor, not standalone diagnosis.
Differential Considerations
Heparin contamination may fail correction, anti-Xa if suspected.
Comparison Tables
Classification Frameworks
Laboratory Notes
- Institutional incubation time and temperature vary; confirm the performing laboratory procedure.
References
Authoritative textbooks, guidelines, and reviews supporting this reference entry. Verify reference intervals, critical limits, and reflex criteria against institutional protocols and current guideline editions.
Textbooks
- McPherson RA, Pincus MR. Henry's Clinical Diagnosis and Management by Laboratory Methods. 24th ed. Elsevier; 2021.
- Rodak BF, Carr JH. Rodak's Hematology: Clinical Principles and Applications. 6th ed. Elsevier; 2020.
- McKenzie SB, Williams JL. Clinical Laboratory Hematology. 4th ed. Pearson; 2022.
CLSI and Professional Guidelines
- Clinical and Laboratory Standards Institute. Collection, Transport, and Processing of Blood Specimens for Testing Plasma-Based Coagulation Assays and Molecular Hemostasis Assays. CLSI document H21-A5. CLSI; 2008.
- Clinical and Laboratory Standards Institute. Collection, Transport, and Processing of Blood Specimens for Testing Plasma-Based Coagulation Assays. CLSI document H21. CLSI.
- Clinical and Laboratory Standards Institute. Defining, Establishing, and Verifying Reference Intervals in the Clinical Laboratory; Approved Standard. CLSI document EP28-A3c. CLSI; 2010.
- Clinical and Laboratory Standards Institute. Management of Critical- and Significant-Risk Results. CLSI guideline GP47-Ed1. CLSI; 2015.
- International Society on Thrombosis and Haemostasis. Guidelines for the diagnosis of von Willebrand disease. ISTH; 2021.
WHO Publications
- World Health Organization. Haemophilia: diagnosis and management. WHO; 2020.
Frequently Asked Questions
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