Overview
Megakaryocytic lineage production, platelet module integrative review.
Classification
| Stage | Bench-recognizable feature |
|---|---|
| Megakaryoblast | Earliest recognizable megakaryocytic precursor, marrow |
| Megakaryocyte | Large multilobed cell, endomitosis |
| Platelet | Peripheral anucleate fragment |
Morphologic Features
Mature megakaryocytes in marrow; platelets on peripheral smear.
Laboratory Characteristics
- MPV/IPF may reflect production when available
Reference Intervals
Clinical and Laboratory Significance
Links production to count and MPV interpretation.
Differential Considerations
Comparison Tables
Classification Frameworks
Laboratory Notes
- Cross-link /academy/hematology/megakaryopoiesis-and-platelet-production for Module 2 content.
References
Authoritative textbooks, guidelines, and reviews supporting this reference entry. Verify reference intervals, critical limits, and reflex criteria against institutional protocols and current guideline editions.
Textbooks
- McPherson RA, Pincus MR. Henry's Clinical Diagnosis and Management by Laboratory Methods. 24th ed. Elsevier; 2021.
- Rodak BF, Carr JH. Rodak's Hematology: Clinical Principles and Applications. 6th ed. Elsevier; 2020.
- McKenzie SB, Williams JL. Clinical Laboratory Hematology. 4th ed. Pearson; 2022.
- Bain BJ. Blood Cells: A Practical Guide. 5th ed. Wiley-Blackwell; 2015.
CLSI and Professional Guidelines
- Clinical and Laboratory Standards Institute. Reference and Selected Performance Standards for the Automated Complete Blood Cell Count (CBC). CLSI document H26-A2. CLSI; 2010.
- Clinical and Laboratory Standards Institute. Defining, Establishing, and Verifying Reference Intervals in the Clinical Laboratory; Approved Standard. CLSI document EP28-A3c. CLSI; 2010.
- Clinical and Laboratory Standards Institute. Management of Critical- and Significant-Risk Results. CLSI guideline GP47-Ed1. CLSI; 2015.
- Clinical and Laboratory Standards Institute. Collection, Transport, and Processing of Blood Specimens for Testing Plasma-Based Coagulation Assays and Molecular Hemostasis Assays; Approved Guideline. CLSI document H21-A5. CLSI; 2017.
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