Overview
Bleeding disorder laboratory pattern comparison, associations not exclusive diagnoses.
Classification
| Disorder | Platelets | PT | aPTT | Key tests | Bleeding pattern |
|---|---|---|---|---|---|
| VWD | Normal (usually) | Normal | Normal or ↑ | VWF:Ag, activity, multimers | Mucocutaneous |
| Hemophilia A | Normal | Normal | Prolonged | FVIII activity | Deep tissue/joints |
| Hemophilia B | Normal | Normal | Prolonged | FIX activity | Deep tissue/joints |
| DIC | Decreased | Prolonged | Prolonged | Fibrinogen, D-dimer trend | Bleeding ± thrombosis |
| Platelet function defect | Normal | Normal | Normal | PFA, aggregation studies | Mucocutaneous |
Morphologic Features
Schistocytes in DIC with MAHA, peripheral smear correlation.
Laboratory Characteristics
- Screening normal does not exclude VWD or platelet function disorder
Reference Intervals
Factor activity and VWF in %, institutional intervals.
Clinical and Laboratory Significance
Patterns suggest differentials, confirmatory testing and clinical correlation required.
Differential Considerations
Multiple disorders may overlap, treat laboratory as pattern support.
Comparison Tables
Classification Frameworks
VWD ISTH classification detail in specialty references, overview only here.
Laboratory Notes
- Treatment context in Academy disease lessons is educational only; laboratory interpretation remains method- and SOP-dependent.
References
Authoritative textbooks, guidelines, and reviews supporting this reference entry. Verify reference intervals, critical limits, and reflex criteria against institutional protocols and current guideline editions.
Textbooks
- McPherson RA, Pincus MR. Henry's Clinical Diagnosis and Management by Laboratory Methods. 24th ed. Elsevier; 2021.
- Rodak BF, Carr JH. Rodak's Hematology: Clinical Principles and Applications. 6th ed. Elsevier; 2020.
- McKenzie SB, Williams JL. Clinical Laboratory Hematology. 4th ed. Pearson; 2022.
CLSI and Professional Guidelines
- Clinical and Laboratory Standards Institute. Collection, Transport, and Processing of Blood Specimens for Testing Plasma-Based Coagulation Assays and Molecular Hemostasis Assays. CLSI document H21-A5. CLSI; 2008.
- Clinical and Laboratory Standards Institute. Collection, Transport, and Processing of Blood Specimens for Testing Plasma-Based Coagulation Assays. CLSI document H21. CLSI.
- Clinical and Laboratory Standards Institute. Defining, Establishing, and Verifying Reference Intervals in the Clinical Laboratory; Approved Standard. CLSI document EP28-A3c. CLSI; 2010.
- Clinical and Laboratory Standards Institute. Management of Critical- and Significant-Risk Results. CLSI guideline GP47-Ed1. CLSI; 2015.
- International Society on Thrombosis and Haemostasis. Guidelines for the diagnosis of von Willebrand disease. ISTH; 2021.
WHO Publications
- World Health Organization. Haemophilia: diagnosis and management. WHO; 2020.
Frequently Asked Questions
Common questions about using this VWD & Hemostasis Disorders . Lookup diseases and disorders Medical Laboratory Library reference in Medical Laboratory Science education.
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VWD & Hemostasis Disorders . Lookup is a Diseases and Disorders entry in the LabPedia Medical Laboratory Library, written for Medical Laboratory Science reference lookup.
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