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Delayed Hemolytic Transfusion Reactions

This Medical Laboratory Science lesson in Blood Bank supports laboratory science learning and laboratory interpretation for medical laboratory students and professionals.

Interpret the delayed hemolytic transfusion reaction (DHTR) laboratory pattern, anamnestic alloantibody response, antibody screen/identification, DAT, and elution, and distinguish a true delayed hemolytic reaction from a delayed serologic reaction (DSTR).

Advanced30 min read15 sectionsBlood Bank
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Learning Objectives

Getting started

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Learning Objectives

Learning Objectives

Section: Learning Objectives

Each objective below describes a transfusion-service laboratory competency, investigating and interpreting adverse transfusion reactions, not delivering bedside treatment.

  • Explain the anamnestic (secondary) alloantibody response that underlies most delayed hemolytic transfusion reactions and why it produces a delayed, rather than immediate, laboratory picture
  • Interpret the delayed-reaction workup panel, antibody screen and identification, DAT, and elution, and recognize the findings pattern that supports DHTR
  • Distinguish a delayed hemolytic transfusion reaction (DHTR, laboratory evidence of hemolysis) from a delayed serologic transfusion reaction (DSTR, new antibody without clinical/laboratory hemolysis)

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